Brock Purdy bounced back from the worst game of his NFL career to throw two touchdown passes, and the San Francisco 49ers clinched the top seed in the NFC by beating the Washington Commanders 27-10 on Sunday.

Philadelphia’s stunning home loss to Arizona, combined with Detroit’s defeat at Dallas on Saturday, allowed the 49ers (12-4) to sure up a first-round bye and home-field advantage before Week 18. A large cheer erupted from the visiting locker room when the Eagles lost.

Washington (4-12) wasn’t much of an obstacle for the Niners, whose only concern coming out of the victory could be the status of Christian McCaffrey. Their do-it-all running back left the game in the third quarter with a right calf injury after gaining 91 scrimmage yards on 18 touches, but he and the starters will now get plenty of time off to rest.

That was one of many offensive contributions for San Francisco, which got touchdown catches from Deebo Samuel and Brandon Aiyuk and a rushing TD from Elijah Mitchell. Purdy, coming off throwing four interceptions in a humbling home loss to Baltimore, was 22 of 28 for 230 yards to reach 4,280 and break Jeff Garcia’s season franchise record of 4,278 set in 2000.

The defense, also looking to atone for some struggles against the Ravens, intercepted Sam Howell twice – once each by Charvarius Ward and Deommodore Lenoir.

Howell added to his NFL lead in interceptions, now 19, after starting only because journeyman Jacoby Brissett was sidelined by a hamstring injury. Coach Ron Rivera benched Howell earlier in the week after pulling him from the previous two games.

The Commanders have lost seven in a row, and as a result of the Cardinals win, could be in line to draft as high as second.

Arizona Cardinals 35-31 Philadelphia Eagles

James Conner ran for a two-yard touchdown with 32 seconds remaining, Kyler Murray threw three TD passes, and the Arizona Cardinals rallied from a 15-point deficit to stun Philadelphia 35-31 on Sunday and disrupt the Eagles’ playoff path.

Former Eagles defensive coordinator Jonathan Gannon returned to Philly and got his biggest win yet as Arizona’s coach. Granted, there haven’t been many of them for the Cardinals (4-12). But the playoff-bound Eagles’ fourth loss this month – and second at home – was a huge setback to their standing in the NFC.

The Eagles (11-5) could have won the NFC East with wins against Arizona and the New York Giants next week. Now, Dallas can win the division with a win next week at Washington, and San Francisco has locked up the top seed in the conference.

Jalen Hurts, who threw three touchdown passes, was picked off in the end zone on a desperate heave to end the game.

The Eagles have played every bit like a team facing a potential one-and-done in the postseason rather than one that could make a second straight trip to the Super Bowl.

There was plenty of blame to go around: a discombobulated offense that included indecisive play-calling late in the game, a running game that never got going and a defense that couldn’t get off the field.

The Cardinals rallied from a 21-6 halftime deficit on the strength of Murray’s two touchdown passes in the third quarter that tied the game at 21-all.

Hurts put the Eagles ahead in the fourth with a 9-yard touchdown pass to Dallas Goedert.

Normally, that would be enough to win a game at the Linc. But Philly’s defense couldn’t hold on. Cornerback Kelee Ringo was flagged for pass interference and the Cardinals used the extra 29 yards to help tie game 28-28 with 5:26 left. Murray hit Michael Wilson for a 5-yard touchdown, giving Arizona three touchdowns on three possessions in the half.

Jake Elliott kicked a 43-yard field goal with 2:33 left to give the Eagles their last lead.

Murray had plenty of time to move the Cardinals into scoring position. He hit Greg Dorch for a 36-yard gain that brought Arizona to the Eagles 5 and set up Conner’s decisive TD.

The Cardinals had 449 total yards of offense.

Carolina Panthers 0-26 Jacksonville Jaguars

Travis Etienne scored twice, including one on his longest run of the season, and the Jacksonville Jaguars ended a four-game skid with a 26-0 shutout of the woeful Carolina Panthers on Sunday.

The Jaguars (9-7) won for the first time in December – and with quarterback Trevor Lawrence (shoulder) watching from the sideline – to set up a regular-season finale at Tennessee that will help decide the AFC South.

The Panthers (2-14) dropped to 0-9 on the road and were held scoreless for the first time since losing to Atlanta in Week 12 in 2002.

Jacksonville now can clinch the division with a victory next weekend. A loss to the Titans would hand the AFC South to the winner of the Houston-Indianapolis game.

Lawrence missed the game with a sprained throwing shoulder, ending his consecutive starts streak at 51. C.J. Beathard completed 17 of 24 passes for 178 yards in his first start since 2020 and played turnover-free football.