Two men killed in a horrific train crash near the South Australia-NSW border have been identified.

Kevin Baker, 57, and Mick Warren, 48, were killed when the Pacific National freight train they were driving collided with a truck on the Barrier Hwy at Bindarrah in South Australia about 10.30am on Sunday.

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“The impact of the crash caused the locomotive to catch fire and several train carriages to derail, blocking the entire highway,” South Australian police said in a statement.

“We are gutted by the loss,” Baker’s sister Wendy told 7NEWS.

The bodies of the two men remain buried in the wreckage as cleanup and recovery operations continued on Monday.

Police have arrested a Queensland truck driver, aged 75, and charged him with two counts of causing death by dangerous driving.

He is due to face court in Port Pirie on Tuesday.

Kevin Baker, 57, (left) and Mick Warren, 48, (right) were killed when the Pacific National freight train they were driving collided with a truck. Credit: 7NEWS

Transport safety authorities are continuing to investigate how the crash occurred.

The train crossing is believed to be signposted with warning signals, with a clear line of sight to oncoming trains.

The road remains closed and SA Police including major crash investigators are being assisted at the scene by NSW Police and other emergency services.

Police advised the road surface was damaged, and will need to be ticked off by safety inspectors before re-opening.

Police arrested a Queensland truck driver and charged him with two counts of causing death by dangerous driving. Credit: 7NEWS

“This will be a long process and the road surface has also sustained damage, so will in turn need to be inspected for safety,” police said.

Blocked for more than 30 hours so far, the highway is Broken Hill’s quickest route to Adelaide.

The highway remains closed as the cleanup and recovery operations continues. Credit: 7NEWS

Train operator Pacific National said in a statement it was an “extremely difficult time” and that the organisation was devastated by the loss of the two men.

A spokesperson for the company said it takes the safety of its employees very seriously and had notified regulators.

“This incident is having a profound impact across the organisation, and our first priority is to ensure the highest level of care for the families of our drivers who have tragically died,” the spokesperson said.

– With AAP